This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for NAA60. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA60 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA60, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:3,158,260–3,159,345 | 299.2 kb | Distal (>10kb) Multiome | 764 | |
| chr16:3,171,474–3,172,591 | 285.9 kb | Distal (>10kb) Multiome | 574 | |
| chr16:3,174,125–3,174,566 | 283.7 kb | Distal (>10kb) Multiome | 371 | |
| chr16:3,175,429–3,175,953 | 282.4 kb | Distal (>10kb) Multiome | 483 | |
| chr16:3,182,514–3,183,488 | 275.2 kb | Distal (>10kb) Multiome | 690 | |
| chr16:3,187,874–3,189,822 | 268.5 kb | Distal (>10kb) Multiome | 679 | |
| chr16:3,191,282–3,192,194 | 266.3 kb | Distal (>10kb) Multiome | 509 | |
| chr16:3,234,780–3,235,610 | 222.8 kb | Distal (>10kb) Multiome | 845 | |
| chr16:3,263,988–3,264,941 | 193.5 kb | Distal (>10kb) Multiome | 923 | |
| chr16:3,282,413–3,283,892 | 174.9 kb | Distal (>10kb) Multiome | 964 | |
| chr16:3,305,073–3,306,009 | 152.5 kb | Distal (>10kb) Multiome | 681 | |
| chr16:3,400,631–3,401,665 | 56.9 kb | Distal (>10kb) Multiome | 927 | |
| chr16:3,443,423–3,443,772 | at TSS | At TSS | 378 | |
| chr16:3,457,535–3,458,643 | 115 bp | At TSS Multiome | 954 | |
| chr16:3,459,681–3,460,205 | 1.7 kb | Proximal (<10kb) | 98 | |
| chr16:3,461,046–3,461,533 | 3.0 kb | Proximal (<10kb) | 81 | |
| chr16:3,500,701–3,501,337 | 42.9 kb | Distal (>10kb) Multiome | 953 | |
| chr16:3,610,900–3,612,357 | 153.6 kb | Distal (>10kb) Multiome | 733 | |
| chr16:3,654,171–3,654,861 | 196.5 kb | Distal (>10kb) Multiome | 445 | |
| chr16:3,716,849–3,718,043 | 259.5 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the NAA60 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.