Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MZT2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MZT2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MZT2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:129,923,163–129,924,117 | 258.6 kb | Distal (>10kb) Multiome | 183 | |
| chr2:130,144,783–130,145,418 | 37.1 kb | Distal (>10kb) Multiome | 89 | |
| chr2:130,181,118–130,182,559 | 264 bp | At TSS Multiome | 790 | |
| chr2:130,183,864–130,184,117 | 1.6 kb | Proximal (<10kb) | 43 | |
| chr2:130,288,447–130,288,984 | 106.5 kb | Distal (>10kb) Multiome | 232 | |
| chr2:130,327,383–130,328,425 | 145.6 kb | Distal (>10kb) Multiome HiCAR | 215 | |
| chr2:130,336,899–130,337,857 | 155.1 kb | Distal (>10kb) Multiome HiCAR | 861 | |
| chr2:130,341,623–130,343,538 | 160.5 kb | Distal (>10kb) Multiome | 1109 | |
| chr2:130,355,375–130,356,704 | 173.8 kb | Distal (>10kb) Multiome | 816 | |
| chr2:130,371,871–130,373,243 | 190.3 kb | Distal (>10kb) Multiome | 651 | |
| chr2:130,391,075–130,391,923 | 209.3 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the MZT2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.