The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MYLIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYLIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYLIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:15,662,157–15,663,390 | 466.1 kb | Distal (>10kb) Multiome HiCAR | 900 | |
| chr6:15,948,931–15,949,913 | 179.6 kb | Distal (>10kb) Multiome | 472 | |
| chr6:16,128,529–16,130,130 | 67 bp | At TSS Multiome | 1070 | |
| chr6:16,130,626–16,131,436 | 1.5 kb | Proximal (<10kb) | 421 | |
| chr6:16,174,497–16,175,068 | 45.8 kb | Distal (>10kb) Multiome | 94 | |
| chr6:16,238,170–16,238,814 | 109.4 kb | Distal (>10kb) Multiome | 433 | |
| chr6:16,331,420–16,332,565 | 203.2 kb | Distal (>10kb) Multiome | 498 |
Genomic view of the MYLIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.