Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MYL9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYL9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYL9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:36,259,130–36,259,999 | 282.0 kb | Distal (>10kb) Multiome | 159 | |
| chr20:36,306,218–36,306,746 | 235.2 kb | Distal (>10kb) Multiome | 148 | |
| chr20:36,399,522–36,399,982 | 141.7 kb | Distal (>10kb) Multiome | 345 | |
| chr20:36,435,969–36,436,607 | 105.1 kb | Distal (>10kb) Multiome | 268 | |
| chr20:36,460,578–36,462,746 | 80.2 kb | Distal (>10kb) Multiome | 955 | |
| chr20:36,540,956–36,541,869 | 94 bp | At TSS Multiome | 305 | |
| chr20:36,542,060–36,542,474 | 564 bp | At TSS | 201 | |
| chr20:36,571,701–36,572,151 | 30.3 kb | Distal (>10kb) Multiome | 361 | |
| chr20:36,572,535–36,575,795 | 32.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr20:36,585,521–36,586,119 | 44.3 kb | Distal (>10kb) Multiome | 314 | |
| chr20:36,604,973–36,606,237 | 64.1 kb | Distal (>10kb) Multiome | 1049 | |
| chr20:36,676,551–36,678,157 | 135.8 kb | Distal (>10kb) Multiome | 370 | |
| chr20:36,745,462–36,746,528 | 204.6 kb | Distal (>10kb) Multiome | 739 | |
| chr20:36,773,223–36,774,655 | 232.4 kb | Distal (>10kb) Multiome | 971 | |
| chr20:36,821,902–36,822,404 | 280.6 kb | Distal (>10kb) Multiome | 177 | |
| chr20:36,835,484–36,836,113 | 294.3 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the MYL9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.