Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MYL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:55,926,651–55,928,471 | 231.4 kb | Distal (>10kb) Multiome | 993 | |
| chr12:55,931,904–55,932,439 | 226.2 kb | Distal (>10kb) Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 217.9 kb | Distal (>10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 191.6 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 184.5 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 161.1 kb | Distal (>10kb) Multiome | 680 | |
| chr12:56,006,888–56,008,461 | 150.7 kb | Distal (>10kb) Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 137.4 kb | Distal (>10kb) Multiome | 364 | |
| chr12:56,041,220–56,042,537 | 116.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr12:56,078,964–56,081,015 | 79.1 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:56,103,918–56,105,302 | 53.9 kb | Distal (>10kb) Multiome | 977 | |
| chr12:56,115,844–56,117,060 | 41.8 kb | Distal (>10kb) Multiome | 958 | |
| chr12:56,117,641–56,119,301 | 40.1 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:56,126,181–56,126,640 | 32.0 kb | Distal (>10kb) Multiome HiCAR | 671 | |
| chr12:56,127,552–56,129,104 | 30.2 kb | Distal (>10kb) Multiome HiCAR | 800 | |
| chr12:56,151,724–56,153,003 | 5.9 kb | Proximal (<10kb) Multiome | 830 | |
| chr12:56,157,307–56,159,499 | 131 bp | At TSS Multiome | 1008 | |
| chr12:56,188,836–56,190,865 | 31.3 kb | Distal (>10kb) Multiome | 954 | |
| chr12:56,221,094–56,222,691 | 63.6 kb | Distal (>10kb) Multiome | 884 | |
| chr12:56,222,996–56,223,487 | 64.8 kb | Distal (>10kb) Multiome | 38 | |
| chr12:56,223,843–56,224,800 | 66.0 kb | Distal (>10kb) Multiome | 765 | |
| chr12:56,257,471–56,258,774 | 100.1 kb | Distal (>10kb) Multiome | 710 | |
| chr12:56,266,608–56,267,683 | 108.7 kb | Distal (>10kb) Multiome | 857 | |
| chr12:56,299,744–56,300,865 | 142.1 kb | Distal (>10kb) Multiome | 923 | |
| chr12:56,315,380–56,316,674 | 157.8 kb | Distal (>10kb) Multiome | 934 | |
| chr12:56,333,366–56,334,588 | 175.6 kb | Distal (>10kb) Multiome | 853 | |
| chr12:56,359,808–56,360,881 | 201.9 kb | Distal (>10kb) Multiome | 860 | |
| chr12:56,448,848–56,449,756 | 290.9 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the MYL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.