Predicted to act upstream of or within hematopoietic stem cell homeostasis. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYCT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYCT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYCT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:151,451,713–151,453,312 | 1245.6 kb | Distal (>10kb) Multiome HiCAR | 1109 | |
| chr6:151,456,653–151,457,328 | 1240.8 kb | Distal (>10kb) Multiome HiCAR | 65 | |
| chr6:152,635,812–152,637,520 | 60.9 kb | Distal (>10kb) Multiome | 412 | |
| chr6:152,681,820–152,683,597 | 15.5 kb | Distal (>10kb) Multiome | 260 | |
| chr6:152,690,079–152,690,500 | 7.4 kb | Proximal (<10kb) | 15 | |
| chr6:152,701,374–152,701,738 | 3.5 kb | Proximal (<10kb) | 42 | |
| chr6:152,701,854–152,701,999 | 4.0 kb | Proximal (<10kb) | 13 | |
| chr6:152,982,060–152,984,380 | 285.4 kb | Distal (>10kb) Multiome | 1096 |
Genomic view of the MYCT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.