This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for MYBBP1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYBBP1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYBBP1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,263,266–4,264,359 | 291.4 kb | Distal (>10kb) Multiome | 729 | |
| chr17:4,365,147–4,367,069 | 190.0 kb | Distal (>10kb) Multiome | 911 | |
| chr17:4,498,488–4,499,859 | 56.5 kb | Distal (>10kb) Multiome | 361 | |
| chr17:4,555,276–4,555,773 | 81 bp | At TSS Multiome | 806 | |
| chr17:4,583,931–4,585,086 | 28.9 kb | Distal (>10kb) Multiome | 323 | |
| chr17:4,703,669–4,704,637 | 148.7 kb | Distal (>10kb) Multiome | 854 | |
| chr17:4,708,553–4,709,232 | 153.3 kb | Distal (>10kb) Multiome | 71 | |
| chr17:4,709,724–4,711,094 | 155.1 kb | Distal (>10kb) Multiome | 771 | |
| chr17:4,730,794–4,732,115 | 176.2 kb | Distal (>10kb) Multiome | 936 | |
| chr17:4,745,124–4,745,511 | 190.1 kb | Distal (>10kb) Multiome | 67 | |
| chr17:4,789,618–4,790,520 | 234.8 kb | Distal (>10kb) Multiome | 816 | |
| chr17:4,795,974–4,796,433 | 240.8 kb | Distal (>10kb) Multiome | 751 | |
| chr17:4,806,693–4,807,619 | 251.7 kb | Distal (>10kb) Multiome | 494 | |
| chr17:4,832,863–4,833,956 | 278.0 kb | Distal (>10kb) Multiome | 730 |
Genomic view of the MYBBP1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.