Enables microtubule binding activity and protein homodimerization activity. Located in centrosome; cytoplasmic microtubule; and intercellular bridge. Part of nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTUS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTUS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTUS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:28,530,994–28,531,548 | 289.1 kb | Distal (>10kb) Multiome | 200 | |
| chr13:28,532,198–28,533,247 | 287.5 kb | Distal (>10kb) Multiome | 397 | |
| chr13:28,545,399–28,546,237 | 274.4 kb | Distal (>10kb) Multiome | 265 | |
| chr13:28,658,912–28,659,587 | 161.2 kb | Distal (>10kb) Multiome | 797 | |
| chr13:28,684,201–28,684,881 | 135.8 kb | Distal (>10kb) Multiome | 106 | |
| chr13:28,704,351–28,704,874 | 115.8 kb | Distal (>10kb) Multiome | 44 | |
| chr13:28,716,279–28,716,910 | 103.7 kb | Distal (>10kb) Multiome | 277 | |
| chr13:28,718,504–28,719,560 | 101.3 kb | Distal (>10kb) Multiome | 517 | |
| chr13:28,819,363–28,820,845 | 381 bp | At TSS Multiome | 339 | |
| chr13:29,077,142–29,077,775 | 257.2 kb | Distal (>10kb) Multiome | 65 | |
| chr13:29,291,492–29,292,885 | 471.9 kb | Distal (>10kb) Multiome HiCAR | 188 | |
| chr13:29,362,838–29,363,286 | 542.8 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr13:29,428,300–29,429,055 | 608.3 kb | Distal (>10kb) Multiome | 248 | |
| chr13:29,594,380–29,596,128 | 775.4 kb | Distal (>10kb) Multiome | 706 |
Genomic view of the MTUS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.