The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for MTPAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTPAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTPAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:30,080,742–30,081,590 | 293.4 kb | Distal (>10kb) Multiome | 64 | |
| chr10:30,160,563–30,161,110 | 213.7 kb | Distal (>10kb) Multiome | 189 | |
| chr10:30,348,845–30,349,638 | 25.2 kb | Distal (>10kb) Multiome | 582 | |
| chr10:30,359,548–30,360,380 | 14.5 kb | Distal (>10kb) Multiome | 215 | |
| chr10:30,374,381–30,374,643 | at TSS | At TSS | 111 | |
| chr10:30,392,543–30,393,007 | 18.3 kb | Distal (>10kb) Multiome | 314 | |
| chr10:30,432,849–30,435,403 | 59.5 kb | Distal (>10kb) Multiome | 1011 | |
| chr10:30,538,047–30,538,841 | 163.9 kb | Distal (>10kb) Multiome HiCAR | 355 | |
| chr10:30,552,960–30,554,430 | 179.6 kb | Distal (>10kb) Multiome | 591 | |
| chr10:30,557,884–30,558,900 | 184.1 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the MTPAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.