Enables several functions, including R-SMAD binding activity; phosphatidylinositol phosphate phosphatase activity; and protein phosphatase binding activity. Involved in several processes, including midbody abscission; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and phosphatidylinositol dephosphorylation. Located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Is active in early phagosome membrane and endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTMR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTMR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTMR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:58,218,800–58,219,654 | 298.5 kb | Distal (>10kb) Multiome | 890 | |
| chr17:58,249,147–58,250,121 | 268.1 kb | Distal (>10kb) Multiome | 737 | |
| chr17:58,324,153–58,325,169 | 193.3 kb | Distal (>10kb) Multiome | 274 | |
| chr17:58,338,012–58,338,430 | 179.7 kb | Distal (>10kb) Multiome | 559 | |
| chr17:58,339,009–58,339,515 | 178.6 kb | Distal (>10kb) Multiome | 382 | |
| chr17:58,351,751–58,352,762 | 165.5 kb | Distal (>10kb) Multiome | 990 | |
| chr17:58,487,466–58,488,518 | 30.0 kb | Distal (>10kb) Multiome | 222 | |
| chr17:58,513,911–58,515,157 | 3.2 kb | Proximal (<10kb) Multiome | 585 | |
| chr17:58,517,239–58,519,377 | 171 bp | At TSS Multiome | 1140 | |
| chr17:58,520,907–58,521,115 | 3.1 kb | Proximal (<10kb) | 116 | |
| chr17:58,527,884–58,528,411 | 10.3 kb | Distal (>10kb) Multiome | 79 | |
| chr17:58,531,392–58,532,430 | 14.2 kb | Distal (>10kb) Multiome | 323 | |
| chr17:58,630,482–58,632,252 | 113.9 kb | Distal (>10kb) Multiome | 1257 | |
| chr17:58,657,864–58,659,830 | 141.3 kb | Distal (>10kb) Multiome | 1269 | |
| chr17:58,669,900–58,670,548 | 152.4 kb | Distal (>10kb) Multiome | 52 | |
| chr17:58,678,911–58,679,743 | 161.7 kb | Distal (>10kb) Multiome | 889 | |
| chr17:58,692,284–58,692,956 | 174.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:58,755,487–58,756,995 | 238.0 kb | Distal (>10kb) Multiome | 682 | |
| chr17:59,565,384–59,566,262 | 1047.8 kb | Distal (>10kb) Multiome HiCAR | 1120 |
Genomic view of the MTMR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.