Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for MTMR12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTMR12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTMR12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:32,173,339–32,175,075 | 138.7 kb | Distal (>10kb) Multiome | 1090 | |
| chr5:32,287,695–32,288,492 | 24.8 kb | Distal (>10kb) Multiome | 161 | |
| chr5:32,311,442–32,311,841 | 1.1 kb | Proximal (<10kb) | 153 | |
| chr5:32,312,016–32,313,764 | 132 bp | At TSS Multiome | 877 | |
| chr5:32,319,349–32,319,840 | 6.4 kb | Proximal (<10kb) | 84 | |
| chr5:32,443,333–32,445,482 | 131.8 kb | Distal (>10kb) Multiome | 960 | |
| chr5:32,463,190–32,463,817 | 150.7 kb | Distal (>10kb) Multiome | 67 | |
| chr5:32,474,004–32,474,924 | 161.4 kb | Distal (>10kb) Multiome | 130 | |
| chr5:32,500,148–32,500,972 | 187.5 kb | Distal (>10kb) Multiome | 96 | |
| chr5:32,585,030–32,586,359 | 272.8 kb | Distal (>10kb) Multiome | 894 |
Genomic view of the MTMR12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.