Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Contributes to nitrite reductase (NO-forming) activity. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTARC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTARC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTARC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:220,271,709–220,273,089 | 514.5 kb | Distal (>10kb) Multiome HiCAR | 984 | |
| chr1:220,527,225–220,529,488 | 258.6 kb | Distal (>10kb) Multiome | 617 | |
| chr1:220,689,932–220,691,083 | 96.6 kb | Distal (>10kb) Multiome HiCAR | 763 | |
| chr1:220,733,095–220,733,546 | 53.7 kb | Distal (>10kb) Multiome | 459 | |
| chr1:220,747,474–220,749,068 | 38.5 kb | Distal (>10kb) Multiome | 799 | |
| chr1:220,776,782–220,777,194 | 9.7 kb | Proximal (<10kb) | 301 | |
| chr1:220,784,901–220,785,693 | 1.2 kb | Proximal (<10kb) | 100 | |
| chr1:220,785,886–220,787,782 | 78 bp | At TSS Multiome | 800 | |
| chr1:220,809,823–220,810,852 | 23.5 kb | Distal (>10kb) Multiome | 265 | |
| chr1:220,878,403–220,880,339 | 92.5 kb | Distal (>10kb) Multiome | 527 | |
| chr1:220,883,958–220,885,196 | 97.7 kb | Distal (>10kb) Multiome | 155 | |
| chr1:220,893,773–220,895,170 | 107.5 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the MTARC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.