MT-ND1

NADH dehydrogenase subunit 1 | NAD1, ND1, MTND1

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Parkinson's disease; and multiple sclerosis. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-9 DE-9.4 Developmental clusters: GC3

Biological processes 23 terms

NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase activity (GO:0003954)aerobic respiration (GO:0009060)aerobic respiration (GO:0009060)membrane (GO:0016020)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial membrane (GO:0031966)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrion (GO:0005739)protein binding (GO:0005515)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)proton transmembrane transport (GO:1902600)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)

Expression (TPM)