This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for MRRF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRRF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRRF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:122,092,682–122,093,762 | 171.5 kb | Distal (>10kb) Multiome | 771 | |
| chr9:122,099,169–122,100,386 | 165.1 kb | Distal (>10kb) Multiome | 262 | |
| chr9:122,159,157–122,160,157 | 105.1 kb | Distal (>10kb) Multiome | 592 | |
| chr9:122,213,553–122,214,655 | 50.8 kb | Distal (>10kb) Multiome | 629 | |
| chr9:122,219,092–122,220,535 | 45.4 kb | Distal (>10kb) Multiome | 158 | |
| chr9:122,228,256–122,229,326 | 36.1 kb | Distal (>10kb) Multiome | 307 | |
| chr9:122,264,447–122,265,544 | 37 bp | At TSS Multiome | 1042 | |
| chr9:122,405,953–122,406,784 | 141.5 kb | Distal (>10kb) Multiome | 118 | |
| chr9:122,562,159–122,562,684 | 297.4 kb | Distal (>10kb) Multiome | 32 |
Genomic view of the MRRF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.