Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPS23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPS23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPS23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:57,554,041–57,555,116 | 295.4 kb | Distal (>10kb) Multiome | 234 | |
| chr17:57,568,350–57,568,969 | 281.3 kb | Distal (>10kb) Multiome | 29 | |
| chr17:57,612,112–57,613,173 | 237.2 kb | Distal (>10kb) Multiome | 230 | |
| chr17:57,662,590–57,663,471 | 187.0 kb | Distal (>10kb) Multiome | 392 | |
| chr17:57,750,076–57,750,566 | 99.7 kb | Distal (>10kb) Multiome | 85 | |
| chr17:57,756,756–57,757,413 | 92.9 kb | Distal (>10kb) Multiome | 131 | |
| chr17:57,783,050–57,783,717 | 66.6 kb | Distal (>10kb) Multiome | 468 | |
| chr17:57,833,107–57,833,593 | 16.8 kb | Distal (>10kb) Multiome | 406 | |
| chr17:57,849,786–57,850,720 | 121 bp | At TSS Multiome | 1079 | |
| chr17:57,851,171–57,852,883 | 2.5 kb | Proximal (<10kb) Multiome | 649 | |
| chr17:57,857,994–57,858,200 | 8.0 kb | Proximal (<10kb) | 332 | |
| chr17:57,860,878–57,862,423 | 11.3 kb | Distal (>10kb) Multiome | 875 | |
| chr17:57,868,191–57,868,869 | 18.5 kb | Distal (>10kb) Multiome | 587 | |
| chr17:57,874,428–57,875,544 | 24.8 kb | Distal (>10kb) Multiome | 639 | |
| chr17:57,892,543–57,893,376 | 42.7 kb | Distal (>10kb) Multiome | 825 | |
| chr17:57,901,269–57,901,796 | 51.6 kb | Distal (>10kb) Multiome | 289 | |
| chr17:57,926,939–57,927,538 | 77.1 kb | Distal (>10kb) Multiome | 259 | |
| chr17:57,954,427–57,955,892 | 105.3 kb | Distal (>10kb) Multiome | 612 | |
| chr17:57,987,092–57,989,001 | 138.3 kb | Distal (>10kb) Multiome HiCAR | 1036 | |
| chr17:58,006,337–58,008,268 | 157.5 kb | Distal (>10kb) Multiome HiCAR | 1147 | |
| chr17:58,082,555–58,084,952 | 233.3 kb | Distal (>10kb) Multiome HiCAR | 835 |
Genomic view of the MRPS23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.