Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL41. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL41 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL41, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,253,801–137,256,036 | 296.6 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 270.7 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,859–137,296,916 | 256.4 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 249.4 kb | Distal (>10kb) Multiome | 790 | |
| chr9:137,316,104–137,316,916 | 235.6 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 144.7 kb | Distal (>10kb) Multiome | 427 | |
| chr9:137,422,664–137,424,024 | 128.6 kb | Distal (>10kb) Multiome | 896 | |
| chr9:137,441,270–137,441,970 | 110.3 kb | Distal (>10kb) Multiome | 568 | |
| chr9:137,453,153–137,455,543 | 97.8 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 92.5 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 90.0 kb | Distal (>10kb) Multiome | 284 | |
| chr9:137,550,368–137,550,599 | 1.3 kb | Proximal (<10kb) | 346 | |
| chr9:137,551,136–137,552,512 | 125 bp | At TSS Multiome | 756 | |
| chr9:137,578,523–137,579,553 | 27.1 kb | Distal (>10kb) Multiome | 910 | |
| chr9:137,589,526–137,591,323 | 38.7 kb | Distal (>10kb) Multiome | 623 | |
| chr9:137,604,440–137,607,003 | 53.6 kb | Distal (>10kb) Multiome | 675 | |
| chr9:137,618,064–137,619,880 | 67.1 kb | Distal (>10kb) Multiome | 867 | |
| chr9:137,723,975–137,724,439 | 172.3 kb | Distal (>10kb) Multiome | 115 | |
| chr9:137,732,255–137,733,025 | 180.8 kb | Distal (>10kb) Multiome | 20 | |
| chr9:137,851,599–137,852,229 | 300.0 kb | Distal (>10kb) Multiome | 104 |
Genomic view of the MRPL41 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.