MROH1

maestro heat like repeat family member 1 | KIAA1833, HEATR7A

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-4 DE-4.32

Biological processes 6 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosome fission (GO:0170064)membrane destabilizing activity (GO:0140912)

Expression (TPM)

TFs regulating MROH1 0 TFs

Transcription factors with Perturb-seq knockdown data for MROH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MROH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MROH1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MROH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:143,877,814–143,879,346	269.5 kb	Distal (>10kb) Multiome	444
chr8:143,941,814–143,942,929	205.8 kb	Distal (>10kb) Multiome	630
chr8:143,943,562–143,944,432	204.0 kb	Distal (>10kb) Multiome	587
chr8:143,951,583–143,954,394	194.2 kb	Distal (>10kb) Multiome	943
chr8:143,972,817–143,973,908	174.5 kb	Distal (>10kb) Multiome	436
chr8:143,976,288–143,977,568	171.0 kb	Distal (>10kb) Multiome	738
chr8:143,989,521–143,991,038	158.0 kb	Distal (>10kb) Multiome	596
chr8:144,049,063–144,051,761	97.4 kb	Distal (>10kb) Multiome	342
chr8:144,060,259–144,061,087	87.3 kb	Distal (>10kb) Multiome	727
chr8:144,078,142–144,079,235	69.4 kb	Distal (>10kb) Multiome	912
chr8:144,082,187–144,083,105	65.5 kb	Distal (>10kb) Multiome	763
chr8:144,094,454–144,095,491	53.1 kb	Distal (>10kb) Multiome	798
chr8:144,103,485–144,105,242	43.7 kb	Distal (>10kb) Multiome	1033
chr8:144,108,038–144,108,663	39.7 kb	Distal (>10kb) Multiome	137
chr8:144,137,565–144,138,500	10.3 kb	Distal (>10kb) Multiome	817
chr8:144,146,820–144,149,073	86 bp	At TSS Multiome	790
chr8:144,266,293–144,267,098	118.5 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	143.5 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	168.1 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	178.9 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	184.0 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	188.9 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	206.5 kb	Distal (>10kb) Multiome	280
chr8:144,358,142–144,359,070	210.5 kb	Distal (>10kb) Multiome	719
chr8:144,369,349–144,369,916	221.7 kb	Distal (>10kb) Multiome	204
chr8:144,372,497–144,372,883	224.7 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	225.9 kb	Distal (>10kb) Multiome	903
chr8:144,408,968–144,410,189	261.4 kb	Distal (>10kb) Multiome	920
chr8:144,427,691–144,429,571	280.6 kb	Distal (>10kb) Multiome	1000
chr8:144,443,691–144,445,047	296.3 kb	Distal (>10kb) Multiome	743

Genome Browser

Genomic view of the MROH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.