This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for MRFAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRFAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRFAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:6,367,437–6,367,936 | 273.0 kb | Distal (>10kb) Multiome | 38 | |
| chr4:6,470,551–6,471,324 | 169.8 kb | Distal (>10kb) Multiome | 373 | |
| chr4:6,472,122–6,472,949 | 168.1 kb | Distal (>10kb) Multiome | 157 | |
| chr4:6,574,723–6,575,464 | 65.6 kb | Distal (>10kb) Multiome | 601 | |
| chr4:6,640,089–6,641,132 | 91 bp | At TSS Multiome | 851 | |
| chr4:6,673,157–6,674,688 | 33.3 kb | Distal (>10kb) Multiome | 920 | |
| chr4:6,709,388–6,710,099 | 69.2 kb | Distal (>10kb) Multiome | 693 | |
| chr4:6,715,775–6,716,910 | 75.5 kb | Distal (>10kb) Multiome | 822 | |
| chr4:6,782,106–6,784,027 | 141.9 kb | Distal (>10kb) Multiome | 886 | |
| chr4:6,908,950–6,910,715 | 268.9 kb | Distal (>10kb) Multiome | 820 |
Genomic view of the MRFAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.