The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for MPP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:28,293,436–28,294,074 | 9.3 kb | Proximal (<10kb) Multiome | 102 | |
| chr10:28,294,922–28,295,114 | 7.9 kb | Proximal (<10kb) | 45 | |
| chr10:28,302,152–28,303,596 | 11 bp | At TSS Multiome | 714 | |
| chr10:28,459,483–28,460,059 | 156.7 kb | Distal (>10kb) Multiome | 45 | |
| chr10:28,518,834–28,519,331 | 216.0 kb | Distal (>10kb) Multiome | 47 | |
| chr10:28,532,042–28,534,170 | 229.8 kb | Distal (>10kb) Multiome | 975 |
Genomic view of the MPP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.