Predicted to enable proton transmembrane transporter activity. Predicted to be involved in Golgi to endosome transport. Located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MON2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MON2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MON2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:62,259,363–62,261,218 | 206.6 kb | Distal (>10kb) Multiome | 1050 | |
| chr12:62,295,652–62,296,695 | 170.8 kb | Distal (>10kb) Multiome | 125 | |
| chr12:62,435,134–62,436,513 | 31.0 kb | Distal (>10kb) Multiome | 442 | |
| chr12:62,466,179–62,467,402 | 46 bp | At TSS Multiome | 866 | |
| chr12:62,471,677–62,472,812 | 4.9 kb | Proximal (<10kb) | 132 | |
| chr12:62,602,250–62,603,979 | 135.9 kb | Distal (>10kb) Multiome | 1165 | |
| chr12:62,646,389–62,647,205 | 180.0 kb | Distal (>10kb) Multiome | 78 | |
| chr12:62,653,374–62,655,092 | 187.2 kb | Distal (>10kb) Multiome | 290 | |
| chr12:62,659,395–62,659,972 | 192.8 kb | Distal (>10kb) Multiome | 177 | |
| chr12:62,673,057–62,673,824 | 206.8 kb | Distal (>10kb) Multiome | 53 | |
| chr12:62,792,786–62,794,262 | 326.6 kb | Distal (>10kb) Multiome HiCAR | 428 |
Genomic view of the MON2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.