The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for MNAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MNAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MNAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:60,485,178–60,486,252 | 248.8 kb | Distal (>10kb) Multiome | 378 | |
| chr14:60,508,535–60,510,247 | 225.7 kb | Distal (>10kb) Multiome | 245 | |
| chr14:60,514,579–60,516,786 | 219.8 kb | Distal (>10kb) Multiome | 517 | |
| chr14:60,637,200–60,638,337 | 96.9 kb | Distal (>10kb) Multiome | 201 | |
| chr14:60,641,851–60,643,218 | 92.3 kb | Distal (>10kb) Multiome | 222 | |
| chr14:60,648,454–60,651,189 | 83.9 kb | Distal (>10kb) Multiome | 790 | |
| chr14:60,655,802–60,657,953 | 77.5 kb | Distal (>10kb) Multiome | 631 | |
| chr14:60,720,299–60,724,768 | 10.4 kb | Distal (>10kb) Multiome | 933 | |
| chr14:60,726,393–60,726,699 | 8.1 kb | Proximal (<10kb) | 2 | |
| chr14:60,726,940–60,727,551 | 7.2 kb | Proximal (<10kb) | 16 | |
| chr14:60,734,617–60,735,251 | at TSS | At TSS | 918 | |
| chr14:60,980,625–60,981,938 | 246.4 kb | Distal (>10kb) Multiome | 866 | |
| chr14:61,254,867–61,255,650 | 520.4 kb | Distal (>10kb) Multiome HiCAR | 219 |
Genomic view of the MNAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.