Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MMP25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMP25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMP25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,751,637–2,753,398 | 294.0 kb | Distal (>10kb) Multiome | 1074 | |
| chr16:2,776,766–2,778,256 | 269.2 kb | Distal (>10kb) Multiome | 828 | |
| chr16:2,867,958–2,868,665 | 178.2 kb | Distal (>10kb) Multiome | 960 | |
| chr16:2,882,042–2,883,813 | 163.6 kb | Distal (>10kb) Multiome | 838 | |
| chr16:2,904,002–2,906,321 | 142.3 kb | Distal (>10kb) Multiome | 994 | |
| chr16:2,911,480–2,912,624 | 134.7 kb | Distal (>10kb) Multiome | 784 | |
| chr16:2,963,159–2,965,475 | 82.6 kb | Distal (>10kb) Multiome | 628 | |
| chr16:2,968,641–2,970,561 | 77.4 kb | Distal (>10kb) Multiome | 1039 | |
| chr16:2,979,651–2,981,140 | 66.1 kb | Distal (>10kb) Multiome | 795 | |
| chr16:2,981,390–2,982,257 | 64.8 kb | Distal (>10kb) Multiome | 460 | |
| chr16:3,003,612–3,004,589 | 42.5 kb | Distal (>10kb) Multiome | 652 | |
| chr16:3,007,583–3,008,956 | 38.0 kb | Distal (>10kb) Multiome | 514 | |
| chr16:3,009,722–3,010,376 | 36.5 kb | Distal (>10kb) Multiome | 395 | |
| chr16:3,017,242–3,018,799 | 28.4 kb | Distal (>10kb) Multiome | 451 | |
| chr16:3,019,969–3,022,268 | 26.3 kb | Distal (>10kb) Multiome | 963 | |
| chr16:3,022,890–3,024,532 | 22.4 kb | Distal (>10kb) Multiome | 933 | |
| chr16:3,027,854–3,029,038 | 18.2 kb | Distal (>10kb) Multiome | 546 | |
| chr16:3,036,222–3,037,148 | 9.7 kb | Proximal (<10kb) Multiome | 256 | |
| chr16:3,045,413–3,047,408 | 342 bp | At TSS Multiome | 510 | |
| chr16:3,058,226–3,060,102 | 12.8 kb | Distal (>10kb) Multiome | 769 | |
| chr16:3,098,550–3,100,475 | 53.7 kb | Distal (>10kb) Multiome | 454 | |
| chr16:3,106,146–3,106,906 | 60.1 kb | Distal (>10kb) Multiome | 851 | |
| chr16:3,123,818–3,124,940 | 77.8 kb | Distal (>10kb) Multiome | 800 | |
| chr16:3,134,425–3,135,445 | 88.5 kb | Distal (>10kb) Multiome | 752 | |
| chr16:3,149,357–3,151,137 | 104.1 kb | Distal (>10kb) Multiome | 975 | |
| chr16:3,152,009–3,153,129 | 106.2 kb | Distal (>10kb) Multiome | 889 | |
| chr16:3,156,990–3,157,742 | 110.8 kb | Distal (>10kb) Multiome | 680 | |
| chr16:3,158,260–3,159,345 | 112.3 kb | Distal (>10kb) Multiome | 764 | |
| chr16:3,171,474–3,172,591 | 125.6 kb | Distal (>10kb) Multiome | 574 | |
| chr16:3,174,125–3,174,566 | 127.8 kb | Distal (>10kb) Multiome | 371 | |
| chr16:3,175,429–3,175,953 | 129.1 kb | Distal (>10kb) Multiome | 483 | |
| chr16:3,182,514–3,183,488 | 136.3 kb | Distal (>10kb) Multiome | 690 | |
| chr16:3,187,874–3,189,822 | 143.0 kb | Distal (>10kb) Multiome | 679 | |
| chr16:3,191,282–3,192,194 | 145.2 kb | Distal (>10kb) Multiome | 509 | |
| chr16:3,234,780–3,235,610 | 188.7 kb | Distal (>10kb) Multiome | 845 | |
| chr16:3,263,988–3,264,941 | 218.0 kb | Distal (>10kb) Multiome | 923 | |
| chr16:3,282,413–3,283,892 | 236.5 kb | Distal (>10kb) Multiome | 964 | |
| chr16:3,305,073–3,306,009 | 258.9 kb | Distal (>10kb) Multiome | 681 |
Genomic view of the MMP25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.