Transcription factors with Perturb-seq knockdown data for MMP24OS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMP24OS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMP24OS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,872,384–34,873,259 | 405.2 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr20:34,874,110–34,874,535 | 403.8 kb | Distal (>10kb) Multiome HiCAR | 357 | |
| chr20:34,875,878–34,877,081 | 401.7 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr20:34,979,568–34,980,289 | 298.2 kb | Distal (>10kb) Multiome | 149 | |
| chr20:35,092,320–35,093,398 | 185.3 kb | Distal (>10kb) Multiome HiCAR | 1139 | |
| chr20:35,146,563–35,147,734 | 130.8 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr20:35,171,731–35,172,358 | 106.1 kb | Distal (>10kb) Multiome | 383 | |
| chr20:35,174,680–35,175,277 | 103.1 kb | Distal (>10kb) Multiome | 635 | |
| chr20:35,262,839–35,263,582 | 14.8 kb | Distal (>10kb) Multiome | 336 | |
| chr20:35,269,197–35,269,766 | 8.6 kb | Proximal (<10kb) Multiome | 447 | |
| chr20:35,277,415–35,278,519 | 46 bp | At TSS Multiome | 575 | |
| chr20:35,284,235–35,285,360 | 6.7 kb | Proximal (<10kb) Multiome | 950 | |
| chr20:35,303,859–35,304,479 | 26.0 kb | Distal (>10kb) Multiome | 484 | |
| chr20:35,454,521–35,455,845 | 177.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr20:35,539,672–35,540,321 | 261.9 kb | Distal (>10kb) Multiome | 311 | |
| chr20:35,541,280–35,542,685 | 264.0 kb | Distal (>10kb) Multiome | 849 |
Genomic view of the MMP24OS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.