Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for MKLN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MKLN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MKLN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:131,105,557–131,107,032 | 221.8 kb | Distal (>10kb) Multiome HiCAR | 786 | |
| chr7:131,109,607–131,110,332 | 217.9 kb | Distal (>10kb) Multiome HiCAR | 678 | |
| chr7:131,327,222–131,328,641 | 14 bp | At TSS Multiome | 963 | |
| chr7:131,513,393–131,514,233 | 185.9 kb | Distal (>10kb) Multiome | 446 | |
| chr7:131,546,665–131,547,151 | 219.0 kb | Distal (>10kb) Multiome | 202 | |
| chr7:131,556,063–131,558,394 | 230.1 kb | Distal (>10kb) Multiome | 671 | |
| chr7:131,604,843–131,605,922 | 277.6 kb | Distal (>10kb) Multiome | 273 | |
| chr7:131,622,932–131,623,631 | 295.4 kb | Distal (>10kb) Multiome | 194 | |
| chr7:131,625,703–131,626,457 | 298.2 kb | Distal (>10kb) Multiome | 315 |
Genomic view of the MKLN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.