Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. Predicted to be part of CENP-A recruiting complex. Predicted to be active in chromosome, centromeric region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIS18BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIS18BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIS18BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:44,961,013–44,963,177 | 291.1 kb | Distal (>10kb) Multiome | 890 | |
| chr14:45,083,317–45,084,737 | 169.1 kb | Distal (>10kb) Multiome | 770 | |
| chr14:45,133,924–45,135,140 | 118.7 kb | Distal (>10kb) Multiome | 799 | |
| chr14:45,135,659–45,136,491 | 117.2 kb | Distal (>10kb) Multiome | 641 | |
| chr14:45,252,483–45,252,787 | 414 bp | At TSS | 107 | |
| chr14:45,252,907–45,254,209 | 104 bp | At TSS Multiome | 1004 | |
| chr14:45,294,661–45,295,649 | 41.9 kb | Distal (>10kb) Multiome | 171 | |
| chr14:45,393,566–45,394,707 | 140.8 kb | Distal (>10kb) Multiome | 127 | |
| chr14:45,550,972–45,551,929 | 298.2 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the MIS18BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.