Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIRLET7A1HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIRLET7A1HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIRLET7A1HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:93,948,645–93,949,108 | 227.4 kb | Distal (>10kb) Multiome | 65 | |
| chr9:93,954,201–93,955,998 | 220.9 kb | Distal (>10kb) Multiome | 228 | |
| chr9:94,030,363–94,031,139 | 145.6 kb | Distal (>10kb) Multiome | 869 | |
| chr9:94,165,559–94,167,324 | 9.6 kb | Proximal (<10kb) Multiome | 1085 | |
| chr9:94,250,394–94,250,997 | 74.4 kb | Distal (>10kb) Multiome | 81 | |
| chr9:94,259,139–94,259,781 | 82.9 kb | Distal (>10kb) Multiome | 663 | |
| chr9:94,374,230–94,375,026 | 198.1 kb | Distal (>10kb) Multiome | 332 |
Genomic view of the MIRLET7A1HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.