This gene produces a long non-coding RNA that acts as a host gene for miR-31. This transcript may be involved in cellular pluripotency and regulate the differentiation of myoblasts and other tissues. This RNA was found to interact with Polycomb repressive proteins to repression transcription of genes involves in cell senescence. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for MIR31HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR31HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR31HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:21,334,615–21,335,758 | 224.5 kb | Distal (>10kb) Multiome | 770 | |
| chr9:21,402,228–21,403,414 | 157.0 kb | Distal (>10kb) Multiome | 255 | |
| chr9:21,504,615–21,505,684 | 54.8 kb | Distal (>10kb) Multiome | 144 | |
| chr9:21,558,668–21,558,994 | 860 bp | At TSS | 86 | |
| chr9:21,559,092–21,560,760 | 76 bp | At TSS Multiome | 437 | |
| chr9:21,696,089–21,697,126 | 136.8 kb | Distal (>10kb) Multiome | 185 | |
| chr9:21,751,963–21,752,478 | 192.3 kb | Distal (>10kb) Multiome | 156 | |
| chr9:21,801,496–21,803,636 | 242.7 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the MIR31HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.