Predicted to enable zinc ion binding activity. Involved in cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIOS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIOS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIOS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,995,280–6,995,919 | 571.4 kb | Distal (>10kb) Multiome HiCAR | 100 | |
| chr7:7,352,864–7,353,400 | 214.0 kb | Distal (>10kb) Multiome | 139 | |
| chr7:7,415,971–7,416,912 | 150.8 kb | Distal (>10kb) Multiome | 282 | |
| chr7:7,566,155–7,567,492 | 119 bp | At TSS Multiome | 741 | |
| chr7:7,581,435–7,582,116 | 14.8 kb | Distal (>10kb) Multiome | 224 | |
| chr7:7,640,013–7,641,632 | 73.6 kb | Distal (>10kb) Multiome | 966 | |
| chr7:7,834,519–7,835,290 | 267.9 kb | Distal (>10kb) Multiome | 123 | |
| chr7:8,261,188–8,262,737 | 695.1 kb | Distal (>10kb) Multiome HiCAR | 655 |
Genomic view of the MIOS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.