Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. Implicated in breast cancer and lung adenocarcinoma. Biomarker of breast cancer; invasive ductal carcinoma; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIER3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIER3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIER3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:56,814,407–56,817,107 | 136.7 kb | Distal (>10kb) Multiome | 908 | |
| chr5:56,909,110–56,910,601 | 42.3 kb | Distal (>10kb) Multiome | 974 | |
| chr5:56,950,605–56,952,748 | 82 bp | At TSS Multiome | 662 | |
| chr5:57,019,246–57,020,109 | 67.6 kb | Distal (>10kb) Multiome | 80 | |
| chr5:57,070,146–57,071,232 | 118.6 kb | Distal (>10kb) Multiome | 102 | |
| chr5:57,095,125–57,095,719 | 143.4 kb | Distal (>10kb) Multiome | 128 | |
| chr5:57,172,984–57,174,839 | 221.6 kb | Distal (>10kb) Multiome | 992 |
Genomic view of the MIER3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.