The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for MGST2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGST2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGST2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,453,063–139,454,584 | 212.0 kb | Distal (>10kb) Multiome | 989 | |
| chr4:139,555,161–139,557,952 | 110.4 kb | Distal (>10kb) Multiome | 818 | |
| chr4:139,656,647–139,657,308 | 8.8 kb | Proximal (<10kb) Multiome | 322 | |
| chr4:139,657,856–139,658,679 | 7.1 kb | Proximal (<10kb) | 233 | |
| chr4:139,663,478–139,663,870 | 1.9 kb | Proximal (<10kb) | 19 | |
| chr4:139,665,282–139,666,449 | 46 bp | At TSS Multiome | 844 | |
| chr4:139,667,275–139,669,052 | 2.5 kb | Proximal (<10kb) Multiome | 181 | |
| chr4:139,669,155–139,671,298 | 4.1 kb | Proximal (<10kb) Multiome | 252 | |
| chr4:139,734,753–139,735,998 | 69.3 kb | Distal (>10kb) Multiome | 441 | |
| chr4:139,815,781–139,816,678 | 150.5 kb | Distal (>10kb) Multiome | 288 | |
| chr4:139,853,016–139,854,104 | 187.7 kb | Distal (>10kb) Multiome | 227 | |
| chr4:139,875,243–139,875,853 | 209.8 kb | Distal (>10kb) Multiome | 198 | |
| chr4:140,150,268–140,153,432 | 486.0 kb | Distal (>10kb) Multiome HiCAR | 813 | |
| chr4:140,153,751–140,154,614 | 488.5 kb | Distal (>10kb) Multiome HiCAR | 861 | |
| chr4:140,349,706–140,350,239 | 684.2 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr4:140,357,429–140,358,616 | 692.2 kb | Distal (>10kb) Multiome HiCAR | 90 |
Genomic view of the MGST2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.