Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MFHAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFHAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFHAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:8,649,084–8,649,803 | 244.2 kb | Distal (>10kb) Multiome | 83 | |
| chr8:8,701,375–8,702,835 | 191.7 kb | Distal (>10kb) Multiome | 599 | |
| chr8:8,743,546–8,744,176 | 149.7 kb | Distal (>10kb) Multiome | 84 | |
| chr8:8,789,557–8,790,044 | 103.8 kb | Distal (>10kb) Multiome | 89 | |
| chr8:8,884,483–8,884,933 | 8.7 kb | Proximal (<10kb) | 102 | |
| chr8:8,891,982–8,894,021 | 40 bp | At TSS Multiome | 613 | |
| chr8:8,963,219–8,963,764 | 69.8 kb | Distal (>10kb) Multiome HiCAR | 278 | |
| chr8:9,002,478–9,003,402 | 109.2 kb | Distal (>10kb) Multiome | 894 | |
| chr8:9,057,454–9,058,557 | 164.5 kb | Distal (>10kb) Multiome | 293 | |
| chr8:9,101,993–9,102,949 | 208.8 kb | Distal (>10kb) Multiome | 546 | |
| chr8:9,123,903–9,124,447 | 230.6 kb | Distal (>10kb) Multiome | 32 | |
| chr8:9,150,157–9,151,970 | 257.1 kb | Distal (>10kb) Multiome | 725 | |
| chr8:9,183,123–9,184,864 | 290.0 kb | Distal (>10kb) Multiome | 265 |
Genomic view of the MFHAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.