Located in several cellular components, including cell junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFAP3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFAP3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFAP3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:169,611,998–169,613,442 | 413.8 kb | Distal (>10kb) Multiome HiCAR | 840 | |
| chr4:169,619,912–169,621,246 | 406.0 kb | Distal (>10kb) Multiome HiCAR | 896 | |
| chr4:169,757,346–169,758,297 | 268.5 kb | Distal (>10kb) Multiome | 724 | |
| chr4:169,774,514–169,775,438 | 251.4 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr4:169,918,815–169,920,220 | 106.6 kb | Distal (>10kb) Multiome HiCAR | 227 | |
| chr4:169,934,787–169,935,471 | 91.4 kb | Distal (>10kb) Multiome | 121 | |
| chr4:170,004,428–170,005,171 | 21.7 kb | Distal (>10kb) Multiome | 112 | |
| chr4:170,017,800–170,018,384 | 8.0 kb | Proximal (<10kb) | 25 | |
| chr4:170,025,638–170,027,809 | 11 bp | At TSS Multiome | 968 | |
| chr4:170,089,100–170,090,754 | 63.7 kb | Distal (>10kb) Multiome | 761 | |
| chr4:170,090,855–170,092,203 | 65.2 kb | Distal (>10kb) Multiome | 192 | |
| chr4:170,109,620–170,111,763 | 84.1 kb | Distal (>10kb) Multiome | 267 | |
| chr4:170,259,234–170,260,354 | 233.4 kb | Distal (>10kb) Multiome | 326 | |
| chr4:170,285,465–170,286,907 | 259.6 kb | Distal (>10kb) Multiome | 211 |
Genomic view of the MFAP3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.