Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:152,528,286–152,529,967 | 1510.4 kb | Distal (>10kb) Multiome HiCAR | 156 | |
| chr5:153,780,742–153,781,671 | 257.9 kb | Distal (>10kb) Multiome | 124 | |
| chr5:153,782,639–153,783,616 | 256.0 kb | Distal (>10kb) Multiome | 207 | |
| chr5:153,824,585–153,825,728 | 213.9 kb | Distal (>10kb) Multiome | 291 | |
| chr5:153,970,477–153,971,077 | 68.3 kb | Distal (>10kb) Multiome HiCAR | 31 | |
| chr5:154,038,273–154,039,479 | 79 bp | At TSS Multiome | 932 | |
| chr5:154,085,657–154,086,553 | 47.2 kb | Distal (>10kb) Multiome | 155 | |
| chr5:154,107,450–154,108,420 | 69.0 kb | Distal (>10kb) Multiome | 133 | |
| chr5:154,150,299–154,151,127 | 111.7 kb | Distal (>10kb) Multiome | 111 | |
| chr5:154,165,484–154,166,441 | 127.0 kb | Distal (>10kb) Multiome | 127 | |
| chr5:154,167,156–154,168,295 | 128.6 kb | Distal (>10kb) Multiome | 221 | |
| chr5:154,189,422–154,191,188 | 151.6 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr5:154,286,422–154,287,475 | 247.7 kb | Distal (>10kb) Multiome | 301 | |
| chr5:154,384,486–154,385,397 | 345.7 kb | Distal (>10kb) Multiome HiCAR | 230 | |
| chr5:154,405,042–154,405,819 | 366.4 kb | Distal (>10kb) Multiome HiCAR | 447 |
Genomic view of the MFAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.