The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for METAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:95,216,693–95,218,575 | 256.5 kb | Distal (>10kb) Multiome | 1001 | |
| chr12:95,442,539–95,444,040 | 30.5 kb | Distal (>10kb) Multiome | 107 | |
| chr12:95,446,296–95,447,252 | 27.4 kb | Distal (>10kb) Multiome | 289 | |
| chr12:95,473,495–95,474,647 | 117 bp | At TSS Multiome | 953 | |
| chr12:95,547,928–95,549,389 | 74.6 kb | Distal (>10kb) Multiome | 471 | |
| chr12:95,551,266–95,551,780 | 77.4 kb | Distal (>10kb) Multiome | 171 | |
| chr12:95,745,876–95,746,868 | 272.2 kb | Distal (>10kb) Multiome | 68 |
Genomic view of the METAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.