The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for METAP1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METAP1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METAP1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:171,893,197–171,894,662 | 105.6 kb | Distal (>10kb) Multiome | 909 | |
| chr2:171,922,015–171,923,029 | 77.5 kb | Distal (>10kb) Multiome | 901 | |
| chr2:171,999,394–172,000,424 | 47 bp | At TSS Multiome | 1019 | |
| chr2:172,080,964–172,081,603 | 81.3 kb | Distal (>10kb) Multiome | 101 | |
| chr2:172,084,336–172,086,019 | 85.4 kb | Distal (>10kb) Multiome | 903 | |
| chr2:172,086,500–172,087,497 | 87.0 kb | Distal (>10kb) Multiome | 254 | |
| chr2:172,101,429–172,103,305 | 103.0 kb | Distal (>10kb) Multiome | 953 | |
| chr2:172,106,181–172,106,692 | 106.5 kb | Distal (>10kb) Multiome | 308 | |
| chr2:172,131,690–172,132,350 | 132.0 kb | Distal (>10kb) Multiome | 102 | |
| chr2:172,172,453–172,173,020 | 172.7 kb | Distal (>10kb) Multiome | 628 | |
| chr2:172,234,493–172,235,728 | 235.2 kb | Distal (>10kb) Multiome | 346 |
Genomic view of the METAP1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.