MEPCE

methylphosphate capping enzyme | FLJ20257, BCDIN3

Enables 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 22 terms

7SK snRNA binding (GO:0097322)7SK snRNP (GO:0120259)O-methyltransferase activity (GO:0008171)RNA 5'-gamma-phosphate methyltransferase activity (GO:1990276)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA methylation (GO:0001510)RNA methyltransferase activity (GO:0008173)RNA methyltransferase activity (GO:0008173)RNA methyltransferase activity (GO:0008173)S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)methyltransferase activity (GO:0008168)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of protein localization to Cajal body (GO:1904871)positive regulation of snRNA transcription by RNA polymerase II (GO:1905382)protein binding (GO:0005515)ribonucleoprotein complex (GO:1990904)snRNA binding (GO:0017069)snRNA metabolic process (GO:0016073)snRNA modification (GO:0040031)snRNA modification (GO:0040031)

Expression (TPM)

TFs regulating MEPCE 0 TFs

Transcription factors with Perturb-seq knockdown data for MEPCE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEPCE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MEPCE

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEPCE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:100,148,262–100,149,663	280.0 kb	Distal (>10kb) Multiome	846
chr7:100,158,247–100,159,079	270.0 kb	Distal (>10kb) Multiome	795
chr7:100,167,090–100,167,783	261.3 kb	Distal (>10kb) Multiome	123
chr7:100,167,894–100,168,793	260.2 kb	Distal (>10kb) Multiome	439
chr7:100,171,153–100,171,887	257.3 kb	Distal (>10kb) Multiome	233
chr7:100,176,986–100,178,152	251.2 kb	Distal (>10kb) Multiome	626
chr7:100,266,531–100,267,045	162.0 kb	Distal (>10kb) Multiome	24
chr7:100,270,225–100,270,813	158.2 kb	Distal (>10kb) Multiome	103
chr7:100,271,732–100,272,774	156.5 kb	Distal (>10kb) Multiome	530
chr7:100,335,652–100,336,470	92.7 kb	Distal (>10kb) Multiome	706
chr7:100,381,682–100,382,670	46.7 kb	Distal (>10kb) Multiome	49
chr7:100,428,059–100,431,175	167 bp	At TSS Multiome	1296
chr7:100,431,643–100,432,380	2.9 kb	Proximal (<10kb)	108
chr7:100,435,379–100,436,927	7.8 kb	Proximal (<10kb) Multiome	931
chr7:100,450,379–100,450,973	21.9 kb	Distal (>10kb) Multiome	785
chr7:100,478,582–100,479,753	50.6 kb	Distal (>10kb) Multiome	842
chr7:100,482,937–100,484,533	54.9 kb	Distal (>10kb) Multiome	677
chr7:100,538,557–100,539,759	110.2 kb	Distal (>10kb) Multiome	858
chr7:100,542,221–100,542,986	113.9 kb	Distal (>10kb) Multiome	274
chr7:100,569,177–100,570,642	140.8 kb	Distal (>10kb) Multiome	855
chr7:100,585,161–100,587,241	157.6 kb	Distal (>10kb) Multiome	966
chr7:100,611,685–100,612,981	183.5 kb	Distal (>10kb) Multiome	767
chr7:100,626,427–100,627,057	198.0 kb	Distal (>10kb) Multiome	415
chr7:100,656,111–100,656,626	227.6 kb	Distal (>10kb) Multiome	653
chr7:100,673,043–100,674,892	244.7 kb	Distal (>10kb) Multiome	934
chr7:100,674,996–100,676,406	247.1 kb	Distal (>10kb) Multiome	439
chr7:100,691,570–100,692,163	263.1 kb	Distal (>10kb) Multiome	364
chr7:100,693,475–100,694,667	265.5 kb	Distal (>10kb) Multiome	607
chr7:100,705,140–100,706,426	277.1 kb	Distal (>10kb) Multiome	962

Genome Browser

Genomic view of the MEPCE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.