The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for MED13L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED13L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED13L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:114,656,987–114,657,820 | 1620.3 kb | Distal (>10kb) Multiome HiCAR | 221 | |
| chr12:115,794,594–115,795,278 | 482.7 kb | Distal (>10kb) Multiome | 113 | |
| chr12:115,916,891–115,917,494 | 360.4 kb | Distal (>10kb) Multiome | 363 | |
| chr12:116,276,119–116,276,527 | 1.2 kb | Proximal (<10kb) | 373 | |
| chr12:116,276,900–116,278,375 | 69 bp | At TSS Multiome | 610 | |
| chr12:116,426,349–116,428,797 | 151.0 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr12:116,506,096–116,506,922 | 228.8 kb | Distal (>10kb) Multiome | 123 | |
| chr12:116,508,269–116,509,006 | 230.8 kb | Distal (>10kb) Multiome | 291 | |
| chr12:116,533,039–116,534,478 | 255.7 kb | Distal (>10kb) Multiome | 430 | |
| chr12:116,694,557–116,695,015 | 417.1 kb | Distal (>10kb) Multiome HiCAR | 37 | |
| chr12:116,697,179–116,697,642 | 419.7 kb | Distal (>10kb) Multiome HiCAR | 129 | |
| chr12:116,737,743–116,738,634 | 460.5 kb | Distal (>10kb) Multiome HiCAR | 852 |
Genomic view of the MED13L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.