Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MDN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MDN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MDN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:89,411,134–89,412,806 | 407.8 kb | Distal (>10kb) Multiome | 540 | |
| chr6:89,432,777–89,434,173 | 386.6 kb | Distal (>10kb) Multiome | 524 | |
| chr6:89,483,120–89,483,667 | 336.3 kb | Distal (>10kb) Multiome | 199 | |
| chr6:89,493,449–89,494,745 | 325.6 kb | Distal (>10kb) Multiome | 266 | |
| chr6:89,496,006–89,496,706 | 323.4 kb | Distal (>10kb) Multiome | 166 | |
| chr6:89,522,599–89,523,543 | 296.7 kb | Distal (>10kb) Multiome | 138 | |
| chr6:89,588,903–89,590,722 | 229.4 kb | Distal (>10kb) Multiome | 245 | |
| chr6:89,638,049–89,639,180 | 181.0 kb | Distal (>10kb) Multiome | 783 | |
| chr6:89,668,262–89,668,525 | 9.5 kb | Proximal (<10kb) | 77 | |
| chr6:89,816,927–89,817,285 | 2.5 kb | Proximal (<10kb) | 7 | |
| chr6:89,817,396–89,818,338 | 2.0 kb | Proximal (<10kb) Multiome | 165 | |
| chr6:89,819,010–89,820,467 | 32 bp | At TSS Multiome | 929 | |
| chr6:89,829,059–89,830,308 | 10.1 kb | Distal (>10kb) Multiome | 769 | |
| chr6:89,890,967–89,891,702 | 71.6 kb | Distal (>10kb) Multiome | 96 |
Genomic view of the MDN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.