The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for MCM9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCM9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCM9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:118,650,262–118,652,597 | 242.6 kb | Distal (>10kb) Multiome | 979 | |
| chr6:118,709,068–118,709,910 | 184.7 kb | Distal (>10kb) Multiome | 530 | |
| chr6:118,786,272–118,787,718 | 107.2 kb | Distal (>10kb) Multiome | 189 | |
| chr6:118,893,171–118,895,350 | 245 bp | At TSS Multiome | 1078 | |
| chr6:118,896,637–118,896,775 | 2.4 kb | Proximal (<10kb) | 273 | |
| chr6:118,903,566–118,904,607 | 9.7 kb | Proximal (<10kb) Multiome | 97 | |
| chr6:118,934,206–118,935,563 | 40.8 kb | Distal (>10kb) Multiome | 909 | |
| chr6:118,993,752–118,994,494 | 99.8 kb | Distal (>10kb) Multiome | 119 | |
| chr6:119,026,545–119,028,642 | 132.8 kb | Distal (>10kb) Multiome | 152 | |
| chr6:119,034,732–119,036,201 | 141.2 kb | Distal (>10kb) Multiome | 248 | |
| chr6:119,037,796–119,038,720 | 144.0 kb | Distal (>10kb) Multiome | 230 | |
| chr6:119,077,736–119,079,370 | 184.5 kb | Distal (>10kb) Multiome HiCAR | 903 |
Genomic view of the MCM9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.