This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome. Alternately spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for MBOAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MBOAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MBOAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:20,210,960–20,213,169 | 120 bp | At TSS Multiome | 824 | |
| chr6:20,271,867–20,273,198 | 60.3 kb | Distal (>10kb) Multiome | 294 | |
| chr6:20,332,337–20,333,567 | 120.4 kb | Distal (>10kb) Multiome | 112 | |
| chr6:20,400,839–20,404,835 | 189.2 kb | Distal (>10kb) Multiome | 1246 | |
| chr6:20,466,756–20,467,411 | 254.6 kb | Distal (>10kb) Multiome | 156 |
Genomic view of the MBOAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.