Enables tubulin-tyrosine carboxypeptidase. Predicted to be involved in brain development. Is active in microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MATCAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MATCAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MATCAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:66,924,739–66,925,515 | 258.9 kb | Distal (>10kb) Multiome | 395 | |
| chr16:66,933,957–66,934,849 | 249.5 kb | Distal (>10kb) Multiome HiCAR | 931 | |
| chr16:67,000,412–67,001,423 | 182.9 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr16:67,013,778–67,014,584 | 169.8 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr16:67,017,916–67,018,379 | 165.9 kb | Distal (>10kb) Multiome HiCAR | 530 | |
| chr16:67,028,567–67,029,938 | 154.9 kb | Distal (>10kb) Multiome HiCAR | 1003 | |
| chr16:67,109,102–67,110,434 | 74.1 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 33.2 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 28.5 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 22.9 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 20.5 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 14.4 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 9.6 kb | Proximal (<10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 5.7 kb | Proximal (<10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 101 bp | At TSS Multiome | 886 | |
| chr16:67,185,256–67,185,693 | 1.6 kb | Proximal (<10kb) Multiome | 740 | |
| chr16:67,191,949–67,192,449 | 8.2 kb | Proximal (<10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 15.8 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 43.1 kb | Distal (>10kb) Multiome | 909 | |
| chr16:67,236,439–67,237,267 | 52.8 kb | Distal (>10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 63.6 kb | Distal (>10kb) Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 65.1 kb | Distal (>10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 78.5 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 95.4 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 142.9 kb | Distal (>10kb) Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 209.5 kb | Distal (>10kb) Multiome | 377 | |
| chr16:67,396,006–67,396,718 | 212.5 kb | Distal (>10kb) Multiome | 375 | |
| chr16:67,399,230–67,399,872 | 215.6 kb | Distal (>10kb) Multiome | 211 | |
| chr16:67,415,996–67,416,812 | 232.5 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 244.3 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 247.2 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 297.3 kb | Distal (>10kb) Multiome | 1002 |
Genomic view of the MATCAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.