This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for MARK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,800,231–44,800,829 | 278.7 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 271.2 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 234.5 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 188.4 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 175.5 kb | Distal (>10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 172.6 kb | Distal (>10kb) Multiome | 645 | |
| chr19:44,913,546–44,915,671 | 164.1 kb | Distal (>10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 152.1 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 124.0 kb | Distal (>10kb) Multiome | 835 | |
| chr19:45,001,031–45,002,639 | 77.9 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 40.2 kb | Distal (>10kb) Multiome | 800 | |
| chr19:45,075,125–45,076,814 | 2.8 kb | Proximal (<10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 866 bp | At TSS Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 13.7 kb | Distal (>10kb) Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 99.2 kb | Distal (>10kb) Multiome | 899 | |
| chr19:45,234,200–45,234,822 | 155.3 kb | Distal (>10kb) Multiome | 105 | |
| chr19:45,250,821–45,251,491 | 171.9 kb | Distal (>10kb) Multiome | 397 | |
| chr19:45,340,431–45,341,201 | 261.5 kb | Distal (>10kb) Multiome | 363 | |
| chr19:45,370,064–45,371,122 | 291.4 kb | Distal (>10kb) Multiome | 592 |
Genomic view of the MARK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.