This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for MARCHF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARCHF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARCHF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:126,735,879–126,736,525 | 294.3 kb | Distal (>10kb) Multiome | 84 | |
| chr5:126,747,828–126,748,496 | 282.3 kb | Distal (>10kb) Multiome | 495 | |
| chr5:126,776,292–126,778,844 | 253.6 kb | Distal (>10kb) Multiome | 1113 | |
| chr5:126,839,262–126,839,804 | 191.0 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr5:127,029,529–127,031,804 | 122 bp | At TSS Multiome | 986 | |
| chr5:127,040,873–127,041,835 | 10.8 kb | Distal (>10kb) Multiome | 329 | |
| chr5:127,072,928–127,073,820 | 42.9 kb | Distal (>10kb) Multiome | 757 | |
| chr5:127,079,734–127,081,090 | 49.7 kb | Distal (>10kb) Multiome | 341 | |
| chr5:127,228,773–127,229,922 | 198.9 kb | Distal (>10kb) Multiome HiCAR | 517 | |
| chr5:127,289,796–127,291,714 | 260.0 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr5:127,324,468–127,325,160 | 294.3 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the MARCHF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.