MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Transcription factors with Perturb-seq knockdown data for MARCHF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARCHF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARCHF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:16,178,616–16,180,665 | 669 bp | At TSS Multiome | 507 | |
| chr5:16,187,713–16,187,937 | 7.9 kb | Proximal (<10kb) | 44 | |
| chr5:16,229,115–16,230,175 | 49.9 kb | Distal (>10kb) Multiome | 207 | |
| chr5:16,378,323–16,379,199 | 199.1 kb | Distal (>10kb) Multiome | 110 | |
| chr5:16,419,918–16,420,591 | 240.5 kb | Distal (>10kb) Multiome HiCAR | 53 | |
| chr5:16,465,184–16,466,419 | 286.1 kb | Distal (>10kb) Multiome HiCAR | 953 |
Genomic view of the MARCHF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.