The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPRE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPRE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPRE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:32,521,770–32,522,231 | 298.0 kb | Distal (>10kb) Multiome | 550 | |
| chr20:32,535,878–32,537,141 | 283.3 kb | Distal (>10kb) Multiome | 665 | |
| chr20:32,582,894–32,585,976 | 236.6 kb | Distal (>10kb) Multiome | 755 | |
| chr20:32,742,092–32,742,834 | 77.5 kb | Distal (>10kb) Multiome | 246 | |
| chr20:32,743,843–32,744,515 | 76.0 kb | Distal (>10kb) Multiome | 356 | |
| chr20:32,761,666–32,763,859 | 57.7 kb | Distal (>10kb) Multiome | 903 | |
| chr20:32,764,497–32,765,161 | 55.1 kb | Distal (>10kb) Multiome | 223 | |
| chr20:32,819,557–32,820,685 | 70 bp | At TSS Multiome | 907 | |
| chr20:32,950,448–32,950,932 | 130.8 kb | Distal (>10kb) Multiome | 85 | |
| chr20:32,974,370–32,975,976 | 155.1 kb | Distal (>10kb) Multiome | 138 | |
| chr20:32,976,142–32,976,882 | 156.6 kb | Distal (>10kb) Multiome | 240 | |
| chr20:33,014,111–33,015,188 | 194.6 kb | Distal (>10kb) Multiome | 255 |
Genomic view of the MAPRE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.