The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,237,368–19,238,388 | 140.3 kb | Distal (>10kb) Multiome | 509 | |
| chr17:19,317,172–19,317,657 | 60.4 kb | Distal (>10kb) Multiome | 467 | |
| chr17:19,362,100–19,363,673 | 14.9 kb | Distal (>10kb) Multiome | 804 | |
| chr17:19,377,561–19,379,155 | 538 bp | At TSS Multiome | 877 | |
| chr17:19,386,868–19,387,884 | 9.5 kb | Proximal (<10kb) Multiome | 305 | |
| chr17:19,433,247–19,433,662 | 55.8 kb | Distal (>10kb) Multiome | 30 | |
| chr17:19,455,896–19,456,558 | 78.4 kb | Distal (>10kb) Multiome | 43 | |
| chr17:19,457,529–19,459,378 | 80.3 kb | Distal (>10kb) Multiome | 100 | |
| chr17:19,460,682–19,461,395 | 83.5 kb | Distal (>10kb) Multiome | 93 | |
| chr17:19,507,283–19,508,789 | 130.4 kb | Distal (>10kb) Multiome HiCAR | 842 | |
| chr17:19,519,787–19,520,274 | 142.2 kb | Distal (>10kb) Multiome | 130 | |
| chr17:19,533,700–19,534,412 | 156.1 kb | Distal (>10kb) Multiome | 488 | |
| chr17:19,579,724–19,580,220 | 202.1 kb | Distal (>10kb) Multiome | 101 | |
| chr17:19,645,969–19,646,517 | 268.4 kb | Distal (>10kb) Multiome | 116 | |
| chr17:19,647,149–19,649,280 | 269.7 kb | Distal (>10kb) Multiome | 1126 | |
| chr17:19,744,539–19,745,417 | 367.3 kb | Distal (>10kb) Multiome HiCAR | 325 |
Genomic view of the MAPK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.