MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1 | HPK1

Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC3

Biological processes 21 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)JNK cascade (GO:0007254)MAP kinase kinase kinase kinase activity (GO:0008349)MAP kinase kinase kinase kinase activity (GO:0008349)MAP kinase kinase kinase kinase activity (GO:0008349)cell population proliferation (GO:0008283)cellular response to phorbol 13-acetate 12-myristate (GO:1904628)cytoplasm (GO:0005737)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)membrane (GO:0016020)peptidyl-serine phosphorylation (GO:0018105)positive regulation of MAPK cascade (GO:0043410)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)

Expression (TPM)

TFs regulating MAP4K1 0 TFs

Transcription factors with Perturb-seq knockdown data for MAP4K1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP4K1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAP4K1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP4K1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:38,319,279–38,320,342	299.0 kb	Distal (>10kb) Multiome	359
chr19:38,335,358–38,337,514	283.1 kb	Distal (>10kb) Multiome	898
chr19:38,361,454–38,362,809	256.8 kb	Distal (>10kb) Multiome	604
chr19:38,374,176–38,375,269	244.2 kb	Distal (>10kb) Multiome	1041
chr19:38,385,485–38,386,937	232.9 kb	Distal (>10kb) Multiome	156
chr19:38,387,065–38,389,471	230.8 kb	Distal (>10kb) Multiome	591
chr19:38,394,369–38,395,035	224.2 kb	Distal (>10kb) Multiome	191
chr19:38,402,504–38,403,738	215.8 kb	Distal (>10kb) Multiome	940
chr19:38,417,766–38,418,568	200.8 kb	Distal (>10kb) Multiome	407
chr19:38,434,539–38,435,128	184.0 kb	Distal (>10kb) Multiome	238
chr19:38,452,620–38,453,510	165.7 kb	Distal (>10kb) Multiome	355
chr19:38,506,710–38,507,745	111.6 kb	Distal (>10kb) Multiome	369
chr19:38,514,956–38,515,568	103.6 kb	Distal (>10kb) Multiome	404
chr19:38,565,090–38,565,701	53.5 kb	Distal (>10kb) Multiome	164
chr19:38,595,857–38,597,322	22.5 kb	Distal (>10kb) Multiome	478
chr19:38,617,752–38,619,569	133 bp	At TSS Multiome	835
chr19:38,622,158–38,622,847	3.3 kb	Proximal (<10kb)	35
chr19:38,647,137–38,648,653	28.7 kb	Distal (>10kb) Multiome	856
chr19:38,666,103–38,666,668	47.4 kb	Distal (>10kb) Multiome	317
chr19:38,683,677–38,684,144	64.8 kb	Distal (>10kb) Multiome	678
chr19:38,734,491–38,735,702	116.5 kb	Distal (>10kb) Multiome	338
chr19:38,735,981–38,737,634	118.2 kb	Distal (>10kb) Multiome	493
chr19:38,754,913–38,755,455	136.3 kb	Distal (>10kb) Multiome	12
chr19:38,831,191–38,832,119	213.0 kb	Distal (>10kb) Multiome	931
chr19:38,849,166–38,852,789	233.2 kb	Distal (>10kb) Multiome	1139
chr19:38,869,729–38,870,536	251.2 kb	Distal (>10kb) Multiome	350
chr19:38,899,267–38,900,530	281.0 kb	Distal (>10kb) Multiome	886

Genome Browser

Genomic view of the MAP4K1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.