MAN2B1

mannosidase alpha class 2B member 1 | LAMAN, MANB

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Developmental clusters: GC2

Biological processes 17 terms

alpha-mannosidase activity (GO:0004559)alpha-mannosidase activity (GO:0004559)alpha-mannosidase activity (GO:0004559)azurophil granule lumen (GO:0035578)carbohydrate binding (GO:0030246)carbohydrate metabolic process (GO:0005975)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)glycoprotein catabolic process (GO:0006516)glycoprotein catabolic process (GO:0006516)lysosomal lumen (GO:0043202)lysosomal lumen (GO:0043202)lysosomal lumen (GO:0043202)lysosome (GO:0005764)mannose metabolic process (GO:0006013)

Expression (TPM)

TFs regulating MAN2B1 0 TFs

Transcription factors with Perturb-seq knockdown data for MAN2B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN2B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAN2B1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN2B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:11,597,206–11,598,107	1059.9 kb	Distal (>10kb) Multiome HiCAR	914
chr19:12,365,585–12,366,054	291.6 kb	Distal (>10kb) Multiome	577
chr19:12,400,090–12,401,657	256.2 kb	Distal (>10kb) Multiome	671
chr19:12,440,217–12,441,483	216.3 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	172.6 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	161.9 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	105.8 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	85.7 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	46.5 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	17.1 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	9.6 kb	Proximal (<10kb) Multiome	126
chr19:12,656,871–12,657,566	201 bp	At TSS Multiome	254
chr19:12,664,457–12,664,721	2.0 kb	Proximal (<10kb)	64
chr19:12,666,317–12,667,225	9.4 kb	Proximal (<10kb) Multiome	495
chr19:12,669,351–12,669,939	12.2 kb	Distal (>10kb) Multiome	777
chr19:12,672,121–12,672,300	5.4 kb	Proximal (<10kb)	206
chr19:12,676,416–12,676,669	9.7 kb	Proximal (<10kb)	276
chr19:12,681,003–12,682,117	24.1 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	39.3 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	45.8 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	65.1 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	66.7 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	77.4 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	79.8 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	100.4 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	108.9 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	118.0 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	120.5 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	125.4 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	132.6 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	134.1 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	136.3 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	144.5 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	149.2 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	168.4 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	175.3 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	176.6 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	181.1 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	183.5 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	190.4 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	210.3 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	216.0 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	224.1 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	228.0 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	233.6 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	256.0 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	262.0 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	276.4 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	281.1 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	288.6 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	299.8 kb	Distal (>10kb) Multiome	747
chr19:14,528,857–14,530,279	1872.1 kb	Distal (>10kb) Multiome HiCAR	842

Genome Browser

Genomic view of the MAN2B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.