This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for MAN1A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN1A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN1A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:119,077,736–119,079,370 | 271.0 kb | Distal (>10kb) Multiome | 903 | |
| chr6:119,326,302–119,327,278 | 23.0 kb | Distal (>10kb) Multiome | 173 | |
| chr6:119,340,412–119,342,097 | 8.5 kb | Proximal (<10kb) Multiome | 314 | |
| chr6:119,347,500–119,347,680 | 2.1 kb | Proximal (<10kb) | 409 | |
| chr6:119,347,969–119,350,913 | 98 bp | At TSS Multiome | 1086 | |
| chr6:119,830,134–119,831,420 | 480.9 kb | Distal (>10kb) Multiome HiCAR | 124 | |
| chr6:120,930,265–120,932,413 | 1582.1 kb | Distal (>10kb) Multiome HiCAR | 257 |
Genomic view of the MAN1A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.