This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for MALT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MALT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MALT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:58,424,566–58,425,218 | 246.5 kb | Distal (>10kb) Multiome | 69 | |
| chr18:58,511,990–58,512,628 | 159.1 kb | Distal (>10kb) Multiome | 126 | |
| chr18:58,556,324–58,556,895 | 114.9 kb | Distal (>10kb) Multiome | 131 | |
| chr18:58,628,791–58,629,668 | 42.2 kb | Distal (>10kb) Multiome | 156 | |
| chr18:58,670,687–58,672,355 | 60 bp | At TSS Multiome | 783 | |
| chr18:58,694,693–58,695,388 | 23.6 kb | Distal (>10kb) Multiome | 196 | |
| chr18:58,768,204–58,768,929 | 97.1 kb | Distal (>10kb) Multiome | 427 | |
| chr18:58,808,329–58,808,800 | 137.1 kb | Distal (>10kb) Multiome | 44 | |
| chr18:58,829,548–58,830,499 | 158.5 kb | Distal (>10kb) Multiome | 168 | |
| chr18:58,846,800–58,849,106 | 176.4 kb | Distal (>10kb) Multiome | 416 | |
| chr18:58,863,566–58,864,932 | 192.9 kb | Distal (>10kb) Multiome | 286 | |
| chr18:58,867,169–58,867,750 | 196.0 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the MALT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.